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$1.06
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2026-08-28 16:00:00 EDT-$0.02
Healthcare
Biotechnology
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Tempest Therapeutics Inc. is an oncology company, currently in the clinical development phase, dedicated to advancing novel small molecule drugs designed to ...

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$1.06
-1.85%-$0.02
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Tempest Therapeutics, Inc. (TPST) is a clinical-stage company focused on small-molecule drug development in oncology, with an emphasis on mechanisms that influence the immune microenvironment of tumors. Rather than pursuing conventional cytotoxic or single-target approaches, the company’s strategy centers on combining targeted and immune-mediated pathways to improve the anti-tumor response. ...Tempest Therapeutics, Inc. (TPST) is a clinical-stage company focused on small-molecule drug development in oncology, with an emphasis on mechanisms that influence the immune microenvironment of tumors. Rather than pursuing conventional cytotoxic or single-target approaches, the company’s strategy centers on combining targeted and immune-mediated pathways to improve the anti-tumor response. Business and product/service focus: The company develops and advances product candidates through preclinical and clinical testing, aiming to identify therapies that can be evaluated in solid tumors and other oncology settings. Based on the provided company description, two prominent clinical candidates are TPST-1495 and TPST-1120. TPST-1495 is described as a dual inhibitor of prostaglandin E2 signaling via EP2 and EP4 receptors, intended to interfere with a pathway frequently associated with immune suppression in the tumor microenvironment. TPST-1120 is described as a targeted blocker of peroxisome proliferator-activated receptor alpha (PPAR-α), also being advanced in solid tumor indications. In addition to these small-molecule programs, the company is also described as exploring TREX-1, a cellular enzyme implicated in regulating innate immune responses in cancer. This suggests a broader R&D effort to identify and validate immune-relevant mechanisms that may be addressed either directly via small molecules or through targeted pathway modulation. The company also references a “clinical-stage CAR-T” characterization in some sources; however, the detailed pipeline provided in the overview is primarily centered on small-molecule candidates. Cost structure and BOM/operations: As a development-stage biotech, Tempest’s “bill of materials” is not a typical manufacturing BOM but rather a cost structure driven by R&D and clinical development activities—medicinal chemistry, formulation/CMC work, toxicology, clinical trial execution (site monitoring, enrollment, patient management), and regulatory compliance. For early-stage companies, costs often dominate revenues, especially while programs are still in Phase 1 or early clinical evaluation. Financial and performance context (high level): The provided financial snapshot indicates profitability and cash flow pressures typical of clinical-stage biopharma (e.g., negative or zero-like margins in the snapshot, and negative free cash flow/return metrics). Such patterns are common for firms prioritizing pipeline advancement, where funding requirements are met through equity issuance, venture/strategic capital, and/or financing rounds. Key people and governance: The CEO is Matthew (Matt) Angel, Ph.D., listed as President/Chief Executive Officer and board member. Leadership experience includes prior executive and co-founding roles in other life-science companies, supporting Tempest’s ability to advance oncology therapeutics through development and commercialization planning. Wishes/trajectory: The company’s near-term objective is to generate clinical and translational evidence for its lead candidates, progress them through subsequent clinical stages, and potentially establish partnerships or additional financing pathways as data accumulates. Longer term, success would depend on demonstrating safety, target engagement/mechanism validity, and clinically meaningful anti-tumor activity in oncology trials, ultimately enabling regulatory review and commercialization if efficacy and benefit-risk are established.
Founded
2011
Employees
4
CEO
Matthew Angel
Full Name
Tempest Therapeutics, Inc.
Sector
Healthcare
Industry
Biotechnology
ROE
-1270.11%
Market Cap
$0.02B
Current Ratio
0.38
WACC
4.85%
ROIC
-864.55%

Contact Information

415 798 8589
2000 Sierra Point Parkway, Brisbane, CA 94005

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