Tempest Therapeutics Inc. is an oncology company, currently in the clinical development phase, dedicated to advancing novel small molecule drugs designed to ...
Tempest Therapeutics, Inc. (TPST) is a clinical-stage company focused on small-molecule drug development in oncology, with an emphasis on mechanisms that influence the immune microenvironment of tumors. Rather than pursuing conventional cytotoxic or single-target approaches, the company’s strategy centers on combining targeted and immune-mediated pathways to improve the anti-tumor response. ...Tempest Therapeutics, Inc. (TPST) is a clinical-stage company focused on small-molecule drug development in oncology, with an emphasis on mechanisms that influence the immune microenvironment of tumors. Rather than pursuing conventional cytotoxic or single-target approaches, the company’s strategy centers on combining targeted and immune-mediated pathways to improve the anti-tumor response.
Business and product/service focus: The company develops and advances product candidates through preclinical and clinical testing, aiming to identify therapies that can be evaluated in solid tumors and other oncology settings. Based on the provided company description, two prominent clinical candidates are TPST-1495 and TPST-1120. TPST-1495 is described as a dual inhibitor of prostaglandin E2 signaling via EP2 and EP4 receptors, intended to interfere with a pathway frequently associated with immune suppression in the tumor microenvironment. TPST-1120 is described as a targeted blocker of peroxisome proliferator-activated receptor alpha (PPAR-α), also being advanced in solid tumor indications.
In addition to these small-molecule programs, the company is also described as exploring TREX-1, a cellular enzyme implicated in regulating innate immune responses in cancer. This suggests a broader R&D effort to identify and validate immune-relevant mechanisms that may be addressed either directly via small molecules or through targeted pathway modulation. The company also references a “clinical-stage CAR-T” characterization in some sources; however, the detailed pipeline provided in the overview is primarily centered on small-molecule candidates.
Cost structure and BOM/operations: As a development-stage biotech, Tempest’s “bill of materials” is not a typical manufacturing BOM but rather a cost structure driven by R&D and clinical development activities—medicinal chemistry, formulation/CMC work, toxicology, clinical trial execution (site monitoring, enrollment, patient management), and regulatory compliance. For early-stage companies, costs often dominate revenues, especially while programs are still in Phase 1 or early clinical evaluation.
Financial and performance context (high level): The provided financial snapshot indicates profitability and cash flow pressures typical of clinical-stage biopharma (e.g., negative or zero-like margins in the snapshot, and negative free cash flow/return metrics). Such patterns are common for firms prioritizing pipeline advancement, where funding requirements are met through equity issuance, venture/strategic capital, and/or financing rounds.
Key people and governance: The CEO is Matthew (Matt) Angel, Ph.D., listed as President/Chief Executive Officer and board member. Leadership experience includes prior executive and co-founding roles in other life-science companies, supporting Tempest’s ability to advance oncology therapeutics through development and commercialization planning.
Wishes/trajectory: The company’s near-term objective is to generate clinical and translational evidence for its lead candidates, progress them through subsequent clinical stages, and potentially establish partnerships or additional financing pathways as data accumulates. Longer term, success would depend on demonstrating safety, target engagement/mechanism validity, and clinically meaningful anti-tumor activity in oncology trials, ultimately enabling regulatory review and commercialization if efficacy and benefit-risk are established.
YoYYoY means Year-over-Year. It compares the latest annual value with the previous annual value to show long-term trend strength.
QoQQoQ means Quarter-over-Quarter. It compares the latest quarter with the immediately previous quarter to show short-term momentum changes.
RevenueThe total money that came through the front door from selling things, before paying a single bill. Think of it as the grand total of every credit card swipe from customers. (YoY compares this year to last year's performance, while QoQ compares the current three months to the previous three).
$0
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Net IncomeThe absolute bottom line. If the company paid every single supplier, employee, banker, and tax collector, this is the actual money left in their pocket at the end of the day.
$-26.3M
+37.2%
+81.1%
Gross MarginThe basic markup. If they sell a $100 pair of sneakers, this percentage tells you how much of that price tag is profit right after paying for the rubber and shoelaces, but before paying for things like store rent or TV commercials.
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Operating MarginThe 'day job' efficiency score. Out of every dollar a customer spends, this shows how many cents the company keeps after making the product AND paying for all the everyday corporate overhead (like salaries, marketing, and keeping the lights on).
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Net MarginThe final take-home percentage. When you strip away every conceivable cost, tax, and interest payment, this is the exact number of cents the company truly gets to keep from every dollar in sales.
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Free Cash FlowThe holy grail of corporate cash. It's the spendable, physical money left over after the business pays for its daily operations AND buys the big, expensive upgrades (like new factories or servers) it needs to survive. This is the 'free' money they can use to pay dividends or buy back stock.
$-26.8M
+19.8%
+63.4%
FCF MarginThe ultimate cash conversion rate. It shows how good the company is at turning regular sales directly into cold, hard, spendable cash. A high percentage means the business is an absolute cash-printing machine.
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Debt / EquityThe financial risk gauge. It compares how much of the company's empire was built using borrowed money (loans) versus the owners' own money (shareholders). A high number means they are heavily leveraged and playing a riskier game; a low number means they are playing it safe.
122.1%
+52.0%
-172.6%
Current RatioThe 12-month survival check. It simply compares the cash they have right now (plus things they can quickly turn into cash) against the immediate bills they absolutely must pay this year. A score above 1 means they have enough in the wallet to cover the upcoming bills without panicking.
2.50x
+12.7%
-48.4%
Total AssetsThe absolute size of the company's empire. It bundles together absolutely everything of value they own—from the cash in the register and the inventory in the warehouse, to the software patents in the vault and the factories on the ground.