Entrada Therapeutics, Inc. operates as a biotechnology enterprise dedicated to pioneering endosomal escape vehicle (EEV) therapeutics, specifically engineered to tackle a range ...
Entrada Therapeutics, Inc. (NASDAQ: TRDA) is a Boston-based clinical-stage biopharmaceutical company founded in 2016 with the vision to revolutionize the treatment of devastating diseases by making intracellular therapeutics a reality. The company's proprietary Endosomal Escape Vehicle (EEV) platform enables the delivery of a wide range of therapeutic modalities—including oligonucleotides, antibodies, ...Entrada Therapeutics, Inc. (NASDAQ: TRDA) is a Boston-based clinical-stage biopharmaceutical company founded in 2016 with the vision to revolutionize the treatment of devastating diseases by making intracellular therapeutics a reality. The company's proprietary Endosomal Escape Vehicle (EEV) platform enables the delivery of a wide range of therapeutic modalities—including oligonucleotides, antibodies, and enzymes—directly into the cytosol of cells, overcoming a major barrier in drug development: inefficient endosomal escape. By leveraging this platform, Entrada aims to address previously undruggable targets and create a new class of medicines with the potential to transform patient lives.
The company's lead product candidate, ENTR-601-44, is in preclinical development for the treatment of Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1). Additionally, the pipeline includes EEV-PMO-CAG, also targeting myotonic dystrophy type 1, and several other programs in various stages of discovery and development. Entrada's R&D efforts focus on neuromuscular diseases, which represent a significant unmet medical need.
Financially, Entrada has a market capitalization of approximately $268 million as of the latest data, with a current ratio of 10.89, indicating strong liquidity. However, the company is pre-revenue and has incurred net losses, with a TTM net profit margin of -35.4%. The R&D expense to revenue ratio is 30.03, reflecting heavy investment in its pipeline. The company has cash and cash equivalents, with a cash per share of $5.28, providing runway for continued operations.
Key leadership includes CEO Dipal Doshi, who joined in 2017 as the first full-time employee and has led the company's strategic direction. In November 2023, Entrada entered into a collaboration with Vertex Pharmaceuticals to develop novel intracellular therapeutics for various diseases, which includes an upfront payment of $24 million and potential milestone payments, demonstrating external validation and potential revenue streams.
The company recently moved to a new headquarters in the Seaport community of Boston, MA, and employs around 152 people. With a strong scientific foundation, strategic partnerships, and a dedicated team, Entrada Therapeutics is poised to advance its pipeline and deliver innovative medicines to patients in need.
YoYYoY means Year-over-Year. It compares the latest annual value with the previous annual value to show long-term trend strength.
QoQQoQ means Quarter-over-Quarter. It compares the latest quarter with the immediately previous quarter to show short-term momentum changes.
RevenueThe total money that came through the front door from selling things, before paying a single bill. Think of it as the grand total of every credit card swipe from customers. (YoY compares this year to last year's performance, while QoQ compares the current three months to the previous three).
$25.4M
-87.9%
+2.6%
Net IncomeThe absolute bottom line. If the company paid every single supplier, employee, banker, and tax collector, this is the actual money left in their pocket at the end of the day.
$-143.8M
-319.0%
-7.7%
Gross MarginThe basic markup. If they sell a $100 pair of sneakers, this percentage tells you how much of that price tag is profit right after paying for the rubber and shoelaces, but before paying for things like store rent or TV commercials.
+83.9%
-16.1%
+1150.0%
Operating MarginThe 'day job' efficiency score. Out of every dollar a customer spends, this shows how many cents the company keeps after making the product AND paying for all the everyday corporate overhead (like salaries, marketing, and keeping the lights on).
-613.7%
-2851.4%
-3.6%
Net MarginThe final take-home percentage. When you strip away every conceivable cost, tax, and interest payment, this is the exact number of cents the company truly gets to keep from every dollar in sales.
-565.5%
-1916.2%
-4.9%
Free Cash FlowThe holy grail of corporate cash. It's the spendable, physical money left over after the business pays for its daily operations AND buys the big, expensive upgrades (like new factories or servers) it needs to survive. This is the 'free' money they can use to pay dividends or buy back stock.
$-129.6M
-189.7%
+22.2%
FCF MarginThe ultimate cash conversion rate. It shows how good the company is at turning regular sales directly into cold, hard, spendable cash. A high percentage means the business is an absolute cash-printing machine.
-509.6%
-2302.3%
+24.2%
Debt / EquityThe financial risk gauge. It compares how much of the company's empire was built using borrowed money (loans) versus the owners' own money (shareholders). A high number means they are heavily leveraged and playing a riskier game; a low number means they are playing it safe.
16.6%
+20.5%
+13.2%
Current RatioThe 12-month survival check. It simply compares the cash they have right now (plus things they can quickly turn into cash) against the immediate bills they absolutely must pay this year. A score above 1 means they have enough in the wallet to cover the upcoming bills without panicking.
12.53x
+12.4%
-21.7%
Total AssetsThe absolute size of the company's empire. It bundles together absolutely everything of value they own—from the cash in the register and the inventory in the warehouse, to the software patents in the vault and the factories on the ground.