Orchestra BioMed Holdings, Inc. operates as an innovative company in the biomedical sector. Its leading product candidates are BackBeat Cardiac Neuromodulation Therapy ...
BackBeat CNT (AVIM Therapy) is a patented bioelectronic treatment developed for patients with pacemaker indications who suffer from uncontrolled hypertension. It functions by modulating cardiac and autonomic nervous system activity to achieve immediate, substantial, and sustained blood pressure reduction without the need for additional medication or invasive nerve ablation.
Price Range: N/A (Investigational / Partnered)
Pain Points: Uncontrolled hypertension, medication non-compliance, and the need for more effective treatments in patients already receiving pacemaker therapy.
Solutions: Provides blood pressure control via a device-based therapy, potentially reducing the patient's reliance on antihypertensive drugs and lowering cardiovascular risk.
Target Users: Hypertension patients with existing pacemaker indications.
Supply Chain
Medtronic (Strategic development and commercialization partner)Internal R&D teamSpecialized medical component manufacturers
Virtue SAB is a proprietary angioplasty balloon that delivers Sirolimus EFR (Extended Release formulation) to the arterial wall during the procedure. It is designed to provide the therapeutic benefits of a drug-eluting stent—such as preventing restenosis—without leaving a permanent metallic implant in the artery.
Price Range: N/A (Investigational / Partnered)
Pain Points: Restenosis following angioplasty, risks associated with permanent implants (stents), and challenges of treating small or complex vessels.
Solutions: Combines mechanical vessel dilation with site-specific drug delivery, facilitating healing and reducing long-term complications without a permanent metal scaffold.
Target Users: Patients with atherosclerotic artery disease undergoing percutaneous coronary or peripheral interventions.
Supply Chain
Terumo Corporation (Strategic development and commercialization partner)Chemical formulation suppliers for Sirolimus EFRMedical catheter and balloon manufacturing facilities
FreeHold retractors are specialized surgical tools designed to assist in minimally invasive surgical procedures, providing optimal visibility and access to the surgical field while minimizing tissue trauma.
Price Range: N/A
Pain Points: Difficulty accessing deep or confined surgical sites, excessive tissue trauma caused by standard retraction methods.
Solutions: Improved surgical site visualization and procedural efficiency.
Target Users: Surgeons and hospitals performing minimally invasive surgeries.
Supply Chain
Surgical instrument manufacturing partnersGlobal healthcare distribution networks
