Why is Sutro Biopharma Stock Falling On Wednesday?
Sutro Biopharma, Inc. (NASDAQ:STRO) shares are trading lower on Wednesday as the company faces challenges following its recent update on the STRO-004 Phase 1 study.

Sutro Biopharma, Inc. is a clinical-stage biotechnology company focused on the discovery, development, and manufacturing of innovative therapeutic products. Its primary objective ...
Plutux is not an investment adviser. Market data and AI-generated analysis are for information and education only, not investment advice. Disclaimer
Est. EPS $-1.66 · Revenue $13.61M · 3 analysts
Est. EPS $-1.55 · Revenue $13.59M · 4 analysts
Est. EPS $-8.03 · Revenue $49.89M · 7 analysts
Est. EPS $-2.02 · Revenue $8.58M · 1 analysts
| Metric | Latest | YoYYoY means Year-over-Year. It compares the latest annual value with the previous annual value to show long-term trend strength. | QoQQoQ means Quarter-over-Quarter. It compares the latest quarter with the immediately previous quarter to show short-term momentum changes. |
|---|---|---|---|
| RevenueThe total money that came through the front door from selling things, before paying a single bill. Think of it as the grand total of every credit card swipe from customers. (YoY compares this year to last year's performance, while QoQ compares the current three months to the previous three). | $102.5M | +65.2% | -32.3% |
| Net IncomeThe absolute bottom line. If the company paid every single supplier, employee, banker, and tax collector, this is the actual money left in their pocket at the end of the day. | $-191.1M | +16.0% | -0.1% |
| Gross MarginThe basic markup. If they sell a $100 pair of sneakers, this percentage tells you how much of that price tag is profit right after paying for the rubber and shoelaces, but before paying for things like store rent or TV commercials. | +92.9% | +5.1% | +9.6% |
| Operating MarginThe 'day job' efficiency score. Out of every dollar a customer spends, this shows how many cents the company keeps after making the product AND paying for all the everyday corporate overhead (like salaries, marketing, and keeping the lights on). | -102.4% | +73.4% | -49.0% |
| Net MarginThe final take-home percentage. When you strip away every conceivable cost, tax, and interest payment, this is the exact number of cents the company truly gets to keep from every dollar in sales. | -186.5% | +49.1% | -47.8% |
| Free Cash FlowThe holy grail of corporate cash. It's the spendable, physical money left over after the business pays for its daily operations AND buys the big, expensive upgrades (like new factories or servers) it needs to survive. This is the 'free' money they can use to pay dividends or buy back stock. | $-178.9M | +8.1% | +9.4% |
| FCF MarginThe ultimate cash conversion rate. It shows how good the company is at turning regular sales directly into cold, hard, spendable cash. A high percentage means the business is an absolute cash-printing machine. | -174.6% | +44.3% | -33.7% |
| Debt / EquityThe financial risk gauge. It compares how much of the company's empire was built using borrowed money (loans) versus the owners' own money (shareholders). A high number means they are heavily leveraged and playing a riskier game; a low number means they are playing it safe. | -11.8% | -122.8% | +48.8% |
| Current RatioThe 12-month survival check. It simply compares the cash they have right now (plus things they can quickly turn into cash) against the immediate bills they absolutely must pay this year. A score above 1 means they have enough in the wallet to cover the upcoming bills without panicking. | 2.01x | -22.8% | +6.4% |
| Total AssetsThe absolute size of the company's empire. It bundles together absolutely everything of value they own—from the cash in the register and the inventory in the warehouse, to the software patents in the vault and the factories on the ground. | $173.8M | -55.1% | -19.6% |
| Metric | Annual (A vs E) | Annual Surprise | Quarter (A vs E) | Quarter Surprise |
|---|---|---|---|---|
| EPS Surprise | -22.49 vs -17.81 | -26.3% | -2.33 vs -2.19 | -6.2% |
| Revenue Surprise | $102.5M vs $99.2M | +3.3% | $9.8M vs $12.0M | -17.7% |
| Date | Executive | Title | Security | Side | Shares | Price |
|---|---|---|---|---|---|---|
| Jun 5, 2026 | Wigginton Jon Marc | director | Stock Option (right to buy) | A | 10,000 | $26.09 |
| Jun 5, 2026 | Petree Daniel H | director | Stock Option (right to buy) | A | 10,000 | $26.09 |
| Jun 5, 2026 | PANEK JAMES P | director | Stock Option (right to buy) | A | 10,000 | $26.09 |
| Jun 5, 2026 | Lobacki Joseph M | director | Stock Option (right to buy) | A | 10,000 | $26.09 |
| Jun 5, 2026 | Jagpal Sukhi | director | Stock Option (right to buy) | A | 10,000 | $26.09 |
| Name | Title | Compensation | Gender | Year Born | Status |
|---|---|---|---|---|---|
Jane Chung | Chief Executive Officer & Director | USD 1,163,250 | Female | 1971 | Active |
Hans-Peter Gerber | Chief Scientific Officer | USD 771,350 | — | 1964 | Active |
Gregory K. Chow | Chief Financial Officer | USD 520,583 | Male | 1973 | Active |
David Pauling | Chief Administrative Officer & General Counsel | — | Male | 1974 | Active |
Jonathan Fawcett DPHIL MBBS | VP & Head of Clinical Development | — | Male | — | Active |
Regina Cheng | Vice President & Controller | — | Female | — | Active |
James R. Swartz | Founder | — | — | — | Active |
Kari E. Leetch | Senior VP and Head of People & Culture | — | Female | — | Active |
Devendra Luhar | Senior Vice President of Technical Operations | — | Male | — | Active |
Sutro Biopharma, Inc. (NASDAQ:STRO) shares are trading lower on Wednesday as the company faces challenges following its recent update on the STRO-004 Phase 1 study.

– Encouraging early clinical activity i ncluding confirmed and ongoing unconfirmed partial responses with favorable tolerability, and pharmacokinetics (PK) observed in ongoing STRO-004 Phase 1 study – – Strong execution of STRO-004 STRIVE-01 study with rapid enrollment of initial dose escalation cohorts within 7 months; dose optimization ongoing between 4-5 mg/kg – – STRO-006, next-generation integrin 6 (ITGB6)-targeting ADC, is on track to enter the clinic in the third quarter of 2026 – – Second dual-payload iADC program from Sutro's platform under Astellas collaboration expected to enter the clinic in the second half of 2026 – – Strong balance sheet with $164.3 million in cash, cash equivalents and marketable securities as of June 30, 2026, expected to support operations into at least the second quarter of 2028 – SOUTH SAN FRANCISCO, Calif., Aug. 12, 2026 (GLOBE NEWSWIRE) -- Sutro Biopharma, Inc. (Sutro or the Company) (NASDAQ: STRO), a clinical-stage oncology company pioneering site-specific and novel-format antibody drug conjugates (ADCs), today reported its financial results for the second quarter ended June 30, 2026 and recent business highlights.

Wall Street analysts reshuffled their ratings on Friday with some bold calls that could move money fast, including a dramatic target cut on Trade Desk and a fresh Buy on SpaceX as markets brace for next week's inflation data.

Affinity Asset Advisors LLC grew its holdings in shares of Sutro Biopharma, Inc. (NASDAQ: STRO) by 42.9% during the first quarter, according to the company in its most recent filing with the Securities and Exchange Commission. The firm owned 1,069,519 shares of the company's stock after purchasing an additional 321,137 shares during the
