Pharvaris N.V., a late-stage biopharmaceutical company, focuses on the development and commercialization of therapies for rare diseases with unmet needs covering angioedema ...
Pharvaris N.V. (NASDAQ: PHVS) is a biotechnology company focused on addressing significant unmet needs in rare diseases driven by bradykinin biology. The company concentrates on the development and (planned) commercialization of oral therapies targeting the bradykinin B2 receptor. Its lead investigational product, deucrictibant, is designed as a small-molecule antagonist to ...Pharvaris N.V. (NASDAQ: PHVS) is a biotechnology company focused on addressing significant unmet needs in rare diseases driven by bradykinin biology. The company concentrates on the development and (planned) commercialization of oral therapies targeting the bradykinin B2 receptor. Its lead investigational product, deucrictibant, is designed as a small-molecule antagonist to help treat attacks and, in clinical programs, to support prophylaxis to reduce the frequency and severity of hereditary angioedema (HAE) attacks. Pharvaris is also pursuing clinical development in related bradykinin-mediated conditions such as acquired angioedema due to C1-inhibitor deficiency (AAE-C1INH).
From a business perspective, Pharvaris positions itself in the late-stage segment of biopharma, where capital efficiency, clinical execution, and regulatory milestones are central to value creation. The company’s focus on an oral mechanism and disease area with high medical need aims to differentiate therapy convenience and potential adherence advantages versus more traditional approaches that may be injectable or require complex administration pathways.
In terms of products and services, Pharvaris primarily conducts pharmaceutical R&D—progressing a pipeline from formulation and clinical trials toward potential commercialization. The company is developing extended-release and immediate-release oral formulations of deucrictibant, aligning product development with the therapeutic goals of on-demand treatment and longer-term prevention strategies. These formulation efforts are often critical for usability, pharmacokinetic characteristics, and clinical outcomes.
With respect to costs and financial characteristics, the company’s valuation and operating metrics (as reflected in available market/TTM financial ratios) suggest a typical late-stage biotech profile: significant investment and expenditures in development activities, with profitability not yet reflected in margins. The provided financial snapshot indicates negative returns on assets/equity and negative earnings/free cash flow yield measures, consistent with R&D-intensive operations prior to sustained product revenue.
Key leadership includes CEO and co-founder Berndt Modig. The company is headquartered in Zug, Switzerland, and was incorporated in 2015, reflecting an organizational timeline that is relatively young but aligned with the long clinical development cycles typical for rare-disease programs. Headline operational scale is in the ~100–200 employee range (129 reported), consistent with a focused team supporting clinical operations, regulatory activities, and drug-development functions.
Overall, Pharvaris’ strategic “wish” is to bring an effective oral bradykinin B2 antagonist to patients with HAE and related conditions, achieving clinical endpoints and regulatory approval to transition from development toward commercialization. Success would likely depend on robust phase 3 outcomes across indications (treatment and prophylaxis), efficient formulation execution, and the ability to fund and de-risk further commercialization readiness.
YoYYoY means Year-over-Year. It compares the latest annual value with the previous annual value to show long-term trend strength.
QoQQoQ means Quarter-over-Quarter. It compares the latest quarter with the immediately previous quarter to show short-term momentum changes.
RevenueThe total money that came through the front door from selling things, before paying a single bill. Think of it as the grand total of every credit card swipe from customers. (YoY compares this year to last year's performance, while QoQ compares the current three months to the previous three).
$0
—
—
Net IncomeThe absolute bottom line. If the company paid every single supplier, employee, banker, and tax collector, this is the actual money left in their pocket at the end of the day.
$-175.7M
-30.9%
-20.1%
Gross MarginThe basic markup. If they sell a $100 pair of sneakers, this percentage tells you how much of that price tag is profit right after paying for the rubber and shoelaces, but before paying for things like store rent or TV commercials.
—
—
—
Operating MarginThe 'day job' efficiency score. Out of every dollar a customer spends, this shows how many cents the company keeps after making the product AND paying for all the everyday corporate overhead (like salaries, marketing, and keeping the lights on).
—
—
—
Net MarginThe final take-home percentage. When you strip away every conceivable cost, tax, and interest payment, this is the exact number of cents the company truly gets to keep from every dollar in sales.
—
—
—
Free Cash FlowThe holy grail of corporate cash. It's the spendable, physical money left over after the business pays for its daily operations AND buys the big, expensive upgrades (like new factories or servers) it needs to survive. This is the 'free' money they can use to pay dividends or buy back stock.
$-137.2M
-13.7%
+23.8%
FCF MarginThe ultimate cash conversion rate. It shows how good the company is at turning regular sales directly into cold, hard, spendable cash. A high percentage means the business is an absolute cash-printing machine.
—
—
—
Debt / EquityThe financial risk gauge. It compares how much of the company's empire was built using borrowed money (loans) versus the owners' own money (shareholders). A high number means they are heavily leveraged and playing a riskier game; a low number means they are playing it safe.
0.3%
-11.0%
-28.4%
Current RatioThe 12-month survival check. It simply compares the cash they have right now (plus things they can quickly turn into cash) against the immediate bills they absolutely must pay this year. A score above 1 means they have enough in the wallet to cover the upcoming bills without panicking.
10.11x
-19.8%
+6.2%
Total AssetsThe absolute size of the company's empire. It bundles together absolutely everything of value they own—from the cash in the register and the inventory in the warehouse, to the software patents in the vault and the factories on the ground.