OPKO Health, Inc. is a Miami, Florida-based healthcare enterprise operating primarily through two complementary areas: diagnostics and pharmaceuticals. The company is publicly traded on Nasdaq under the symbol OPK and has international activities in the United States, Ireland, Chile, Spain, Israel, Mexico, and other markets. OPKO’s stated strategy is to ...OPKO Health, Inc. is a Miami, Florida-based healthcare enterprise operating primarily through two complementary areas: diagnostics and pharmaceuticals. The company is publicly traded on Nasdaq under the symbol OPK and has international activities in the United States, Ireland, Chile, Spain, Israel, Mexico, and other markets. OPKO’s stated strategy is to build positions in large healthcare markets by combining proprietary technologies, commercial products, laboratory capabilities, and partnerships with larger pharmaceutical organizations.
The diagnostics segment is anchored by BioReference Laboratories, a substantial clinical laboratory business. BioReference provides testing used for disease detection, diagnosis, patient evaluation, treatment selection, and ongoing monitoring. Its services cover routine and specialized areas such as esoteric testing, molecular diagnostics, anatomical pathology, genetics, women’s health, and correctional healthcare. Customers include physician practices, clinics, hospitals, employers, and government organizations. OPKO also offers a point-of-care diagnostic instrument system intended to deliver rapid blood-test results and operates the 4Kscore test, which helps assess the risk of aggressive prostate cancer.
The pharmaceutical segment includes marketed medicines, development-stage candidates, specialty active pharmaceutical ingredients, and international manufacturing and distribution activities. Rayaldee is one of OPKO’s key commercial products. It is indicated for adults with stage 3 or 4 chronic kidney disease and vitamin D insufficiency who have secondary hyperparathyroidism. OPKO’s pipeline has included OPK88004, an investigational oral selective androgen receptor modulator; OPK88003, a once-weekly peptide under development for type 2 diabetes and obesity; and hGH-CTP, a long-acting, once-weekly human growth hormone candidate developed in collaboration with Pfizer. The company has emphasized extended-release versions of established therapeutic proteins as a way to improve dosing convenience and potentially create differentiated products.
OPKO’s pharmaceutical operations also encompass the development, manufacturing, marketing, importation, and distribution of prescription medicines, generics, nutraceuticals, veterinary products, ophthalmic products, food supplements, and over-the-counter products. Its commercial activities span therapeutic areas including cardiovascular disease, vaccines, antibiotics, gastrointestinal conditions, and hormone-related treatments. These businesses create a diversified revenue base but also expose the company to laboratory reimbursement, drug pricing, regulatory approval, manufacturing, inventory, and commercialization risks.
Based on the supplied trailing-twelve-month information, OPKO reported approximately $1.02 billion in market capitalization, a current ratio of about 3.35, and a debt-to-equity ratio of approximately 0.33. The same data indicates negative net income, operating cash flow, and free cash flow, with research and development spending representing roughly 21.3% of revenue and selling, general, and administrative expense about 35.0% of revenue. OPKO’s cost structure therefore reflects both laboratory operating costs and the substantial investment required to develop and commercialize medicines. In a healthcare company, a conventional bill of materials is less informative than laboratory consumables, diagnostic instruments, pharmaceutical active ingredients, manufacturing services, quality systems, clinical-trial costs, and distribution expenses. Phillip Frost, M.D., has served as OPKO’s chairman and chief executive officer since March 2007. The company had approximately 2,275 full-time employees in the supplied company data, placing it in the 2,001-5,000 employee category.
YoYYoY means Year-over-Year. It compares the latest annual value with the previous annual value to show long-term trend strength.
QoQQoQ means Quarter-over-Quarter. It compares the latest quarter with the immediately previous quarter to show short-term momentum changes.
RevenueThe total money that came through the front door from selling things, before paying a single bill. Think of it as the grand total of every credit card swipe from customers. (YoY compares this year to last year's performance, while QoQ compares the current three months to the previous three).
$606.9M
-14.9%
+31.7%
Net IncomeThe absolute bottom line. If the company paid every single supplier, employee, banker, and tax collector, this is the actual money left in their pocket at the end of the day.
$-225.7M
-324.0%
+84.7%
Gross MarginThe basic markup. If they sell a $100 pair of sneakers, this percentage tells you how much of that price tag is profit right after paying for the rubber and shoelaces, but before paying for things like store rent or TV commercials.
+21.1%
-51.6%
+126.8%
Operating MarginThe 'day job' efficiency score. Out of every dollar a customer spends, this shows how many cents the company keeps after making the product AND paying for all the everyday corporate overhead (like salaries, marketing, and keeping the lights on).
-36.1%
-69.2%
+89.6%
Net MarginThe final take-home percentage. When you strip away every conceivable cost, tax, and interest payment, this is the exact number of cents the company truly gets to keep from every dollar in sales.
-37.2%
-398.3%
+88.4%
Free Cash FlowThe holy grail of corporate cash. It's the spendable, physical money left over after the business pays for its daily operations AND buys the big, expensive upgrades (like new factories or servers) it needs to survive. This is the 'free' money they can use to pay dividends or buy back stock.
$-190.8M
+8.5%
-119.9%
FCF MarginThe ultimate cash conversion rate. It shows how good the company is at turning regular sales directly into cold, hard, spendable cash. A high percentage means the business is an absolute cash-printing machine.
-31.4%
-7.5%
-67.0%
Debt / EquityThe financial risk gauge. It compares how much of the company's empire was built using borrowed money (loans) versus the owners' own money (shareholders). A high number means they are heavily leveraged and playing a riskier game; a low number means they are playing it safe.
34.2%
-7.4%
+0.5%
Current RatioThe 12-month survival check. It simply compares the cash they have right now (plus things they can quickly turn into cash) against the immediate bills they absolutely must pay this year. A score above 1 means they have enough in the wallet to cover the upcoming bills without panicking.
3.97x
+15.7%
-7.2%
Total AssetsThe absolute size of the company's empire. It bundles together absolutely everything of value they own—from the cash in the register and the inventory in the warehouse, to the software patents in the vault and the factories on the ground.
Operator: Good day, and welcome to the OPKO Health Second Quarter 2026 Business Highlights and Financial Results Conference Call. Please note this event is being recorded. I would now like to turn the conference over to Ms. Vivian Cervantes of Investor Relations. Please go ahead, ma'am.
Vivian Cervantes: Thank you. Thank you, operator. Good afternoon, everyone. This is Vivian Cervantes with Alliance Advisors IR. Thank you all for joining us on today's call to discuss OPKO Health's financial results for the second quarter 2026. I'd like to remind you that any statements made during this call by management other than statements of historical fact will be considered forward-looking and as such, are subject to risks and uncertainties that could materially affect the company's results. Those forward-looking statements include, without limitation, the various risks described in the company's SEC filings, including the annual report on Form 10-K for the year ended December 31, 2025. Furthermore, this conference call contains time-sensitive information that is accurate only as of the date of the live broadcast, July 27, 2026. Except as required by law, OPKO undertakes no obligation to revise or update any forward-looking statements to reflect events or circumstances after the date of this call. Regarding the format of today's call, Dr. Phillip Frost, Chairman and Chief Executive Officer, will provide opening remarks. Dr. Elias Zerhouni, Vice Chairman and President, will then provide an overview of OPKO's Therapeutics segment as well as BioReference Health. After that, Adam Logal, OPKO's CFO, will review the company's second quarter financial results and discuss OPKO's financial outlook. And then we will open the call to questions. Now I'd like to turn the call over to Dr. Frost.
Phillip Frost: Good afternoon, and thank you for joining us today. During the second quarter, we made meaningful progress in improving operating efficiency and profitability and in advancing our product pipeline. ModeX continues to move forward with its present portfolio of five clinical trial programs in oncology, immunology and vaccines, each with the potential to deliver first and best-in-class medicines. We initiated a Phase I/IIa clinical safety and efficacy study in the U.S. of our GLP-1 glucagon candidate, and we plan to enroll 44 healthy volunteers and presumed MASH patients to assess single-dose tolerability and pharmacokinetics. OPKO Biologics is making progress with its human growth hormone antagonist to treat acromegaly. Its GLP-2 program for patients with short bowel syndrome and its oral PTH to treat hypoparathyroidism. NGENLA, our growth hormone product, partnered with Pfizer continues to increase market penetration as we advance label expansion clinical trials. I'm pleased that we ended the second quarter with a strong cash position and a solid balance sheet that continues to fund our R&D portfolio at a meaningful level, while also returning capital to …