Exelixis, Inc. operates as a biotechnology firm dedicated to combating cancer, primarily focusing on the identification, advancement, and marketing of novel oncological ...
Exelixis, Inc. is a commercially successful, oncology-focused biotechnology company headquartered in Alameda, California. Founded in 1994, the company has evolved over nearly three decades from a genomics-based drug discovery firm into a multi-platform cancer company. Its mission is to innovate cancer treatments and give patients hope for the future, with ...Exelixis, Inc. is a commercially successful, oncology-focused biotechnology company headquartered in Alameda, California. Founded in 1994, the company has evolved over nearly three decades from a genomics-based drug discovery firm into a multi-platform cancer company. Its mission is to innovate cancer treatments and give patients hope for the future, with a focus on both small molecules and biotherapeutics.
The company's approved products include CABOMETYX (cabozantinib) tablets for advanced renal cell carcinoma, and COMETRIQ (cabozantinib) capsules for progressive, metastatic medullary thyroid cancer. These are based on cabozantinib, an inhibitor of multiple tyrosine kinases including MET, AXL, RET, and VEGF receptors. Additionally, Exelixis markets COTELLIC (cobimetinib), an MEK inhibitor used in combination for advanced melanoma, and MINNEBRO (esaxerenone), a non-steroidal mineralocorticoid receptor blocker approved for hypertension in Japan.
Exelixis maintains a robust development pipeline, with candidates such as XL092, an oral tyrosine kinase inhibitor targeting VEGF receptors, MET, AXL, MER, and other kinases; XB002, an antibody-drug conjugate targeting tissue factor for advanced solid tumors and non-Hodgkin's lymphoma; and XL102, an oral CDK7 inhibitor for advanced solid tumors.
The company has extensive partnerships and licensing agreements with major pharmaceutical and biotech entities, including Ipsen Pharma, Takeda, F. Hoffmann-La Roche, Genentech, Bristol-Myers Squibb, Daiichi Sankyo, and others, which support its research and commercialization efforts.
Financially, Exelixis reported a market capitalization of approximately $13.6 billion, with strong profitability metrics. The company has a trailing twelve-month net profit margin of 35.3%, return on equity of 42.5%, and a revenue per share of $9.71. Its enterprise value-to-EBITDA ratio stands at 12.96, indicating a reasonable valuation. The company has a strong balance sheet with a current ratio of 3.456, a debt-to-equity ratio of only 0.09, and substantial free cash flow generation, evidenced by a free cash flow yield of 10.5%.
Under the leadership of President and CEO Michael Morrissey, Ph.D., Exelixis continues to focus on advancing its oncology portfolio, with a commitment to research and development, as evidenced by R&D expenses accounting for 33.8% of revenue. With a team of 1,077 full-time employees, the company is well-positioned to sustain its growth and make a meaningful impact in the fight against cancer.
YoYYoY means Year-over-Year. It compares the latest annual value with the previous annual value to show long-term trend strength.
QoQQoQ means Quarter-over-Quarter. It compares the latest quarter with the immediately previous quarter to show short-term momentum changes.
RevenueThe total money that came through the front door from selling things, before paying a single bill. Think of it as the grand total of every credit card swipe from customers. (YoY compares this year to last year's performance, while QoQ compares the current three months to the previous three).
$2.3B
+7.0%
+2.9%
Net IncomeThe absolute bottom line. If the company paid every single supplier, employee, banker, and tax collector, this is the actual money left in their pocket at the end of the day.
$782.6M
+50.1%
+0.8%
Gross MarginThe basic markup. If they sell a $100 pair of sneakers, this percentage tells you how much of that price tag is profit right after paying for the rubber and shoelaces, but before paying for things like store rent or TV commercials.
+96.4%
-0.1%
-0.0%
Operating MarginThe 'day job' efficiency score. Out of every dollar a customer spends, this shows how many cents the company keeps after making the product AND paying for all the everyday corporate overhead (like salaries, marketing, and keeping the lights on).
+37.6%
+34.8%
-4.0%
Net MarginThe final take-home percentage. When you strip away every conceivable cost, tax, and interest payment, this is the exact number of cents the company truly gets to keep from every dollar in sales.
+33.7%
+40.3%
-2.1%
Free Cash FlowThe holy grail of corporate cash. It's the spendable, physical money left over after the business pays for its daily operations AND buys the big, expensive upgrades (like new factories or servers) it needs to survive. This is the 'free' money they can use to pay dividends or buy back stock.
$844.3M
+33.2%
+24.0%
FCF MarginThe ultimate cash conversion rate. It shows how good the company is at turning regular sales directly into cold, hard, spendable cash. A high percentage means the business is an absolute cash-printing machine.
+36.4%
+24.5%
+20.5%
Debt / EquityThe financial risk gauge. It compares how much of the company's empire was built using borrowed money (loans) versus the owners' own money (shareholders). A high number means they are heavily leveraged and playing a riskier game; a low number means they are playing it safe.
8.0%
-5.8%
+2.8%
Current RatioThe 12-month survival check. It simply compares the cash they have right now (plus things they can quickly turn into cash) against the immediate bills they absolutely must pay this year. A score above 1 means they have enough in the wallet to cover the upcoming bills without panicking.
3.56x
-2.1%
+6.1%
Total AssetsThe absolute size of the company's empire. It bundles together absolutely everything of value they own—from the cash in the register and the inventory in the warehouse, to the software patents in the vault and the factories on the ground.
Kathleen : Good day, ladies and gentlemen, and welcome to the Exelixis Second Quarter 2026 Financial Results Conference Call. My name is Kathleen, and I will be your operator for today. As a reminder, this call is being recorded for replay purposes. I would now like to turn the call over to your host for today, Mr. Andrew Peters, Senior Vice President of Strategy and Investor Relations. Please proceed.
Andrew Peters : Thank you, Kathleen, and thank you all for joining us for the Exelixis Second Quarter 2026 Financial Results Conference Call. Joining me on today's call are Mike Morrissey, our President; and Chris Senner, our Chief Financial Officer; Dana Aftab, our Executive Vice President of Research and Development; and P.J. Haley, our Executive Vice President of Commercial, who will review our progress for the second quarter 2026 ended June 30, 2026. During the call today, we will refer to financial measures not calculated according to generally accepted accounting principles. Please refer to today's press release, which is posted on our website for an explanation of our reasons for using such non-GAAP measures as well as tables deriving these measures from our GAAP results. During the course of this presentation, we will be making forward-looking statements regarding future events and the future performance of the company. This includes statements about possible developments regarding discovery, product development, regulatory, commercial, financial and strategic matters, potential growth opportunities and government drug pricing policies and initiatives. Actual events or results could, of course, differ materially. We refer you to the documents we file from time to time with the Securities and Exchange Commission, which, under the heading Risk Factors, identify important factors that could cause actual results to differ materially from those expressed by the company verbally and in writing today, including, without limitation, risks and uncertainties related to product commercial success, market competition, regulatory review and approval processes, conducting clinical trials, compliance with applicable regulatory requirements, our dependence on collaboration partners and the level of costs associated with the discovery, product development, business development and commercialization activities. With that, I'll turn the call over to Mike.
Michael Morrissey : All right. Thank you, Andrew, and thanks to everyone for joining us on the call today. Exelixis continues to execute across the key elements of our business, positioning the company to deliver on our strategic objectives for 2026 and beyond. We are in the early innings of our next phase of growth as we deliver on our strategy to evolve from a single compound company to one with a pipeline of potential oncology franchise opportunities. Zanzalintinib is poised to transform Exelixis as our next franchise molecule, potentially first with a third-line plus CRC filing that's currently …