Exact Sciences Corporation specializes in developing and distributing cancer screening and diagnostic tools across the United States and internationally. Their key product, ...
Exact Sciences Corporation helps address the cancer continuum—from prevention and early detection to therapy guidance—through its molecular diagnostics platform and test portfolio. The company’s flagship product, Cologuard, is designed for non-invasive colorectal cancer screening by analyzing stool-based DNA and hemoglobin biomarkers associated with colorectal cancer and precancerous conditions. By enabling ...Exact Sciences Corporation helps address the cancer continuum—from prevention and early detection to therapy guidance—through its molecular diagnostics platform and test portfolio. The company’s flagship product, Cologuard, is designed for non-invasive colorectal cancer screening by analyzing stool-based DNA and hemoglobin biomarkers associated with colorectal cancer and precancerous conditions. By enabling earlier identification of at-risk individuals, Cologuard supports routine screening programs and helps shift diagnosis to earlier stages where treatment outcomes can be improved.
Beyond screening, Exact Sciences provides precision oncology tests intended to guide clinical decision-making. The Oncotype DX family of assays uses gene expression profiling to help clinicians understand the biology of specific tumors and select treatment strategies for patients with cancers such as breast, prostate, and colorectal cancer. The portfolio also includes additional specialized tests (e.g., liquid biopsy and other advanced molecular approaches) aimed at improving diagnostic clarity for advanced or hard-to-characterize malignancies. In practice, these tests are positioned within clinical workflows that require reliable biomarkers, consistent lab processes, and evidence-based reporting.
Operationally, Exact Sciences supplies testing services through its distribution network, supported by laboratory operations and regulatory compliance processes typical of diagnostic companies. The business model largely depends on reimbursed diagnostic testing and partnerships/licensing—e.g., the company’s ties to major research and technology collaborators mentioned in the overview—while continuing to invest in product improvements and next-generation diagnostics (including novel blood- and other fluid-based approaches).
From a cost and value perspective, the tests are designed to reduce uncertainty in treatment selection and potentially avoid ineffective therapies by providing more informative molecular or biomarker-based risk and tumor characterization. Commercially, the tests are used by healthcare providers and health systems across the United States and internationally, and Exact Sciences also focuses on solutions tailored for health systems managing diagnostic testing at scale.
Financially, like many growth-stage diagnostics companies, Exact Sciences has historically been characterized by significant R&D and commercialization spend relative to profitability, with metrics in the provided dataset indicating margin pressure at the TTM snapshot. The market-facing profile (e.g., enterprise value and valuation multiples) reflects investor expectations around the long-term adoption of screening and precision oncology solutions.
Key people include CEO Kevin T. Conroy (chairman, president & CEO). The company was founded in 1995 and is headquartered in Madison, Wisconsin.
Finally, the provided notes indicate that Exact Sciences is now part of Abbott (“Exact Sciences is now Abbott”). This matters strategically because integration under a larger healthcare organization can broaden distribution, scale commercial capabilities, and accelerate the development and deployment of cancer prevention, screening, and precision therapy guidance across Abbott’s platform while maintaining Exact Sciences’ diagnostic expertise.
YoYYoY means Year-over-Year. It compares the latest annual value with the previous annual value to show long-term trend strength.
QoQQoQ means Quarter-over-Quarter. It compares the latest quarter with the immediately previous quarter to show short-term momentum changes.
RevenueThe total money that came through the front door from selling things, before paying a single bill. Think of it as the grand total of every credit card swipe from customers. (YoY compares this year to last year's performance, while QoQ compares the current three months to the previous three).
$3.2B
+17.7%
+3.2%
Net IncomeThe absolute bottom line. If the company paid every single supplier, employee, banker, and tax collector, this is the actual money left in their pocket at the end of the day.
$-207.9M
+79.8%
-338.7%
Gross MarginThe basic markup. If they sell a $100 pair of sneakers, this percentage tells you how much of that price tag is profit right after paying for the rubber and shoelaces, but before paying for things like store rent or TV commercials.
+69.7%
+0.2%
+2.1%
Operating MarginThe 'day job' efficiency score. Out of every dollar a customer spends, this shows how many cents the company keeps after making the product AND paying for all the everyday corporate overhead (like salaries, marketing, and keeping the lights on).
-3.1%
+92.0%
-190.7%
Net MarginThe final take-home percentage. When you strip away every conceivable cost, tax, and interest payment, this is the exact number of cents the company truly gets to keep from every dollar in sales.
-6.4%
+82.8%
-324.9%
Free Cash FlowThe holy grail of corporate cash. It's the spendable, physical money left over after the business pays for its daily operations AND buys the big, expensive upgrades (like new factories or servers) it needs to survive. This is the 'free' money they can use to pay dividends or buy back stock.
$356.8M
+378.6%
-36.6%
FCF MarginThe ultimate cash conversion rate. It shows how good the company is at turning regular sales directly into cold, hard, spendable cash. A high percentage means the business is an absolute cash-printing machine.
+11.0%
+306.7%
-38.6%
Debt / EquityThe financial risk gauge. It compares how much of the company's empire was built using borrowed money (loans) versus the owners' own money (shareholders). A high number means they are heavily leveraged and playing a riskier game; a low number means they are playing it safe.
105.1%
-8.4%
+3.7%
Current RatioThe 12-month survival check. It simply compares the cash they have right now (plus things they can quickly turn into cash) against the immediate bills they absolutely must pay this year. A score above 1 means they have enough in the wallet to cover the upcoming bills without panicking.
2.43x
+13.1%
-18.1%
Total AssetsThe absolute size of the company's empire. It bundles together absolutely everything of value they own—from the cash in the register and the inventory in the warehouse, to the software patents in the vault and the factories on the ground.
Operator: Hello, and welcome to the Exact Sciences Third Quarter 2025 Earnings Call. [Operator Instructions] I would now like to turn the conference over to Derek Leckow. You may begin.
Derek Leckow: Thank you for joining us for Exact Sciences' Third Quarter 2025 Conference Call today, November 3, 2025. On the call today are Kevin Conroy, the company's Chairman and CEO; and Aaron Bloomer, our Chief Financial Officer. Earlier this afternoon, Exact Sciences issued a news release detailing our third quarter financial results. This news release and today's presentation are available on our website at exactsciences.com. During today's call, we will make forward-looking statements based on current expectations. Our actual results may be materially different from such statements. Discussions of non-GAAP figures and reconciliations to GAAP figures are included in our earnings press release, and descriptions of the risks and uncertainties associated with Exact Sciences are included in our SEC filings. Both can be accessed through our website. I will now turn the call over to Kevin.
Kevin Conroy: Thanks, Derek. The Exact Sciences team delivered record results in the third quarter. Thanks to the team's execution, we're raising our full year 2025 revenue and adjusted EBITDA guidance. A few highlights from the quarter include growing revenue 20% to $851 million, the highest quarterly growth rate in over 2 years. This was driven by Cologuard's strong brand awareness, inspiring commercial execution, accelerating health systems integrations and a record number of ordering providers. Screening 0.25 million more people in the third quarter versus last year, deepening our relationships with payers and health systems by helping close gaps in guideline recommended cancer screening and launching Cancerguard, our multi-cancer early detection test. Our team is focused on continued commercial effectiveness, expanding access to Cologuard Plus, and driving adoption of our new tests to close a strong year. I will now pass the call to Aaron to discuss our financial results.
Aaron Bloomer: Thanks, Kevin, and good afternoon, everyone. Total revenue grew 20% year-over-year to $851 million, $43 million above the midpoint of our guidance. Growth was led by screening, which increased 22% year-over-year to $666 million. We saw broad-based Cologuard growth led by strong execution from the commercial organization, care gap programs and rescreens. Precision Oncology revenue increased 12% year-over-year on a core basis to $183 million. Growth was led by continued Oncotype DX expansion internationally, U.S. Oncotype DX volumes and partner revenues. We generated $135 million in adjusted EBITDA, an increase of $37 million or 37% year-over-year. Adjusted EBITDA margins expanded 200 basis points to 16%, driven by continued efficiency efforts across our lab, supply chain, G&A and support functions. Non-GAAP gross margins were 71%, down 100 basis points versus last year. The reduction was …