Entera Bio Ltd. is a biopharmaceutical firm in the clinical development phase, dedicated to creating and marketing oral medications composed of large ...
Entera Bio Ltd. (NASDAQ: ENTX) is a clinical-stage biopharmaceutical company focused on changing how patients receive peptide and protein therapies. The company’s core thesis is that certain macromolecule medicines—such as peptides and therapeutic proteins—can be reformulated into an oral, tablet-based delivery format to improve patient convenience and potentially expand real-world ...Entera Bio Ltd. (NASDAQ: ENTX) is a clinical-stage biopharmaceutical company focused on changing how patients receive peptide and protein therapies. The company’s core thesis is that certain macromolecule medicines—such as peptides and therapeutic proteins—can be reformulated into an oral, tablet-based delivery format to improve patient convenience and potentially expand real-world adherence compared with injectable regimens.
From a business perspective, Entera operates primarily in research and development and has not been described as having commercial products yet. Its revenue generation model is therefore typically associated with clinical progress, partnerships, and licensing opportunities rather than large-scale product sales. The company highlights ongoing clinical development activities for its lead programs: EB612, which is in Phase II development for hypoparathyroidism, and EB613, which has completed Phase II studies in osteoporosis and is moving through earlier-stage evaluation (Phase I) for non-healing bone fractures. This pipeline structure suggests a strategy of advancing indications based on the underlying therapeutic concept while continuing to expand the evidence base across relevant patient populations.
Entera also emphasizes collaborative research and licensing. The provided information notes a collaboration arrangement with Amgen Inc. aimed at identifying and advancing potential therapeutic compounds for inflammatory conditions and other serious ailments. Such relationships can help a smaller clinical-stage firm de-risk development, access additional scientific and operational resources, and potentially broaden the therapeutic scope beyond its own internal programs.
Regarding products and technology, Entera positions itself as a “leader” in orally delivered macromolecules, including peptides and other therapeutic proteins, implying proprietary formulation and delivery work that enables oral administration of large molecules. The company’s platform is effectively the differentiating “product,” with individual clinical candidates (e.g., EB612/EB613) serving as embodiments of that approach for specific indications.
Cost and financial profile, based on the supplied snapshot-style metrics, appears consistent with an early, development-focused biotech: profitability metrics such as net income per share and return measures (e.g., ROA/ROE) are negative in the provided data, indicating ongoing investment and limited or no commercial revenue at the time of the snapshot. In addition, valuation and operating cash flow-related ratios are described as unfavorable/negative, which is typical for clinical-stage companies still funding trials and related R&D.
Key people include CEO Miranda J. Toledano, who has served as Entera’s Chief Executive Officer since July 2022 according to the provided leadership references. The company is headquartered in Jerusalem, Israel, and employs roughly a few dozen staff (about 20 full-time employees in the provided data), which aligns with a focused R&D organization.
In terms of “wishes” or near-term priorities implied by its stage, the company’s success is likely tied to clinical milestones—progressing EB612 and EB613 through additional trial phases, generating data that supports regulatory pathways for oral peptide/protein replacement therapies, and maintaining or expanding partnerships that can accelerate development and strengthen pipeline breadth.
YoYYoY means Year-over-Year. It compares the latest annual value with the previous annual value to show long-term trend strength.
QoQQoQ means Quarter-over-Quarter. It compares the latest quarter with the immediately previous quarter to show short-term momentum changes.
RevenueThe total money that came through the front door from selling things, before paying a single bill. Think of it as the grand total of every credit card swipe from customers. (YoY compares this year to last year's performance, while QoQ compares the current three months to the previous three).
$42000
-76.8%
—
Net IncomeThe absolute bottom line. If the company paid every single supplier, employee, banker, and tax collector, this is the actual money left in their pocket at the end of the day.
$-11.4M
-19.9%
-108.6%
Gross MarginThe basic markup. If they sell a $100 pair of sneakers, this percentage tells you how much of that price tag is profit right after paying for the rubber and shoelaces, but before paying for things like store rent or TV commercials.
0.0%
-100.0%
—
Operating MarginThe 'day job' efficiency score. Out of every dollar a customer spends, this shows how many cents the company keeps after making the product AND paying for all the everyday corporate overhead (like salaries, marketing, and keeping the lights on).
-27450.0%
-418.4%
—
Net MarginThe final take-home percentage. When you strip away every conceivable cost, tax, and interest payment, this is the exact number of cents the company truly gets to keep from every dollar in sales.
-27235.7%
-416.7%
—
Free Cash FlowThe holy grail of corporate cash. It's the spendable, physical money left over after the business pays for its daily operations AND buys the big, expensive upgrades (like new factories or servers) it needs to survive. This is the 'free' money they can use to pay dividends or buy back stock.
$-7.5M
-9.6%
-12.2%
FCF MarginThe ultimate cash conversion rate. It shows how good the company is at turning regular sales directly into cold, hard, spendable cash. A high percentage means the business is an absolute cash-printing machine.
-17802.4%
-372.4%
—
Debt / EquityThe financial risk gauge. It compares how much of the company's empire was built using borrowed money (loans) versus the owners' own money (shareholders). A high number means they are heavily leveraged and playing a riskier game; a low number means they are playing it safe.
3.7%
+11.1%
+39.5%
Current RatioThe 12-month survival check. It simply compares the cash they have right now (plus things they can quickly turn into cash) against the immediate bills they absolutely must pay this year. A score above 1 means they have enough in the wallet to cover the upcoming bills without panicking.
3.23x
-57.7%
+13.3%
Total AssetsThe absolute size of the company's empire. It bundles together absolutely everything of value they own—from the cash in the register and the inventory in the warehouse, to the software patents in the vault and the factories on the ground.