Denali Therapeutics Inc.

DNLI

$22.80

-0.22%

N/A-$0.05

Healthcare

Biotechnology

NASDAQ

Active Trading

Denali Therapeutics Inc. is a biopharmaceutical firm, founded in 2013 and based in South San Francisco, California, which focuses on identifying and ...

Key Metrics of DNLI

Snapshot

Latest / TTM · 6 periods

Market Cap

$3.62B

ROCE

-50.8%

EV / EBITDA

-6.93x

+2.2% YoY

FCF Yield

-12.1%

+2.5% YoY

Cash Conversion Cycle

-84.5d

Current Ratio

8.37

Quick take

TTM —

No major risk flags in selected headline metrics.

Key Metrics

Latest / TTM · 6 periods

Valuation trend

Valuation trend table

Metric	2021	2022	2023	2024	2025	TTM
Market CapTotal market value of all shares outstanding.	$5.42B	$3.49B	$2.95B	$3.35B	$2.90B	$3.62B
Enterprise ValueCompany value including debt and cash adjustments.	$5.19B	$3.33B	$2.87B	$3.23B	$2.73B	$3.44B
EV / SalesHow many dollars investors pay per dollar of sales.	106.67x	30.73x	8.69x	0.00x	0.00x	955.76x
EV / EBITDAValuation multiple versus operating earnings before non-cash charges.	-18.37x	-10.56x	-22.36x	-6.54x	-5.48x	-6.93x
Net Debt / EBITDALeverage ratio using net debt divided by EBITDA.	0.81	0.50	0.58	0.26	0.34	0.35

Returns + ROCE gauge

ROCE latest

-50.8%

Prev year -53.1%

Returns + ROCE gauge table

Metric	2021	2022	2023	2024	2025	TTM
ROEProfit generated from shareholders' equity.	-30.2%	-31.3%	-14.1%	-34.4%	-50.6%	-55.3%
ROAProfit generated from total assets.	-20.7%	-22.3%	-12.6%	-30.8%	-44.8%	-44.2%
ROICReturn generated on invested operating capital.	-49.4%	-30.1%	-13.7%	-56.5%	-55.6%	-62.9%
ROCEOperating return on long-term capital used.	-28.8%	-31.1%	-18.3%	-38.3%	-53.1%	-50.8%
Earnings YieldEarnings as a percentage of market value.	-5.4%	-9.3%	-4.9%	-12.6%	-17.7%	-12.0%

Cash flow quality

Cash flow quality table

Metric	2021	2022	2023	2024	2025	TTM
FCFFCash flow available to all capital providers.	$-219.89M	$-262.55M	$-370.93M	$-363.61M	$-422.10M	$-437.46M
FCFECash flow available to equity holders after debt flows.	$-219.89M	$-262.55M	$-370.93M	$-395.94M	$-430.27M	$-438.83M
FCF YieldFree cash flow divided by market capitalization.	-4.1%	-7.5%	-12.6%	-10.8%	-14.6%	-12.1%
Income QualityHow well accounting earnings are backed by cash flow.	0.73	0.75	2.47	0.82	0.81	0.85
Capex / OCFShare of operating cash flow spent on capital expenditures.	-4.0%	-7.3%	-3.6%	-4.6%	-2.3%	-0.8%

Operating efficiency

Operating efficiency table

Metric	2021	2022	2023	2024	2025	TTM
DSOAverage days to collect cash from customers.	9.2d	31.2d	3.8d	0.0d	0.0d	397.7d
DIOAverage days inventory stays before being sold.	0.0d	0.0d	0.0d	0.0d	0.0d	260.3d
DPOAverage days the company takes to pay suppliers.	0.0d	0.0d	0.0d	0.0d	108.7d	742.5d
Operating CycleTime from buying inventory to collecting receivables.	9.2d	31.2d	3.8d	0.0d	0.0d	658.0d
Cash Conversion CycleNet days cash is tied in operations.	9.2d	31.2d	3.8d	0.0d	-108.7d	-84.5d

Snapshot

Latest / TTM: —

Market Cap

$3.62B

ROE

-55.3%

FCF Yield

-12.1%

Current Ratio

8.37

Supply Chain of DNLI

Upstream / Downstream / Proxies

Upstream

Lonza Group AGSWX:LONNOrsini Specialty PharmacyContract Research Organizations (CROs)Cell line and reagent suppliers (multiple)GS Gene Expression System (Lonza proprietary technology)

Downstream

Biogen Inc.NASDAQ:BIIBOrsini Specialty PharmacyRoyalty Pharma plcNASDAQ:RPRX Sanofi SANASDAQ:SNY Takeda Pharmaceutical Company LimitedNYSE:TAK

Proxies

Ionis Pharmaceuticals Inc.NASDAQ:IONS Biogen Inc.NASDAQ:BIIB Alkermes plcNASDAQ:ALKS AC Immune SANASDAQ:ACIU Ultragenyx Pharmaceutical Inc.NASDAQ:RARE

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Plutux is not an investment adviser. Market data and AI-generated analysis are for information and education only, not investment advice. Disclaimer