Creative Medical Technology Holdings Successfully Completes Enrollment and Treatment Across Entire FDA-Cleared ADAPT Trial, Including Opioid Cohort, Advancing CELZ-201 / Olastrocel Toward RMAT Evaluation and Phase 3 Planning
All patients enrolled and treated across original and FDA-cleared expansion cohorts Positive safety and early efficacy signals continue to support late-stage development planning for Olastrocel in chronic lower back pain With enrollment and treatment completed, ADAPT-related clinical execution expenses are expected to decrease as the program transitions into follow-up, data maturation and regulatory planning Company believes reduced enrollment- and treatment-related expenditures should help preserve capital, extend operating runway and support continued Phase 3 preparation without the immediate need for additional fundraising Company remains fully engaged in patient follow-up, data collection, RMAT evaluation and preparation for Phase 3 discussions with FDA for a broader chronic lower back pain population Olastrocel positioned as a potential non-surgical, non-opioid regenerative therapy for a large underserved market PHOENIX, Aug. 20, 2026 (GLOBE NEWSWIRE) -- Creative Medical Technology Holdings, Inc. (NASDAQ: CELZ) (“Creative Medical” or the “Company”), a clinical-stage biotechnology company advancing regenerative medicine solutions, today announced that all patients have now been enrolled and treated across the Company's entire FDA-cleared ADAPT clinical trial evaluating CELZ-201 / Olastrocel, including the original study cohorts and the FDA-cleared opioid expansion cohort. CELZ-201, also known as Olastrocel, is the Company's proprietary perinatal tissue-derived, allogeneic regenerative cell therapy candidate being evaluated for chronic lower back pain associated with degenerative disc disease.
