Replimune Group, Inc. (NASDAQ: REPL) is a clinical-stage biotechnology company headquartered in Woburn, Massachusetts, founded in 2015 with the mission to transform cancer treatment by pioneering the development of oncolytic immunotherapies. The company leverages its proprietary Immuno-STAT (Immuno-Stimulating Antibody and Tumor-targeted) platform to engineer novel therapeutic candidates designed to activate ...Replimune Group, Inc. (NASDAQ: REPL) is a clinical-stage biotechnology company headquartered in Woburn, Massachusetts, founded in 2015 with the mission to transform cancer treatment by pioneering the development of oncolytic immunotherapies. The company leverages its proprietary Immuno-STAT (Immuno-Stimulating Antibody and Tumor-targeted) platform to engineer novel therapeutic candidates designed to activate the body's immune system against malignant cells. Its lead product candidate, RP1, is a selectively replicating herpes simplex virus type 1 (HSV-1) engineered to express GM-CSF and a fusogenic protein, enhancing tumor cell killing and immune activation. RP1 is in Phase I/II clinical trials for various solid tumors and Phase II trials for cutaneous squamous cell carcinoma. The company is also developing RP2, which encodes an anti-CTLA-4 antibody-like protein to counteract immune suppression, and RP3, which expresses immune-activating proteins to stimulate T cells, both in early clinical trials. Replimune went public in July 2018 and has raised significant capital to advance its pipeline. As of the latest data, the company has 465 full-time employees, with a market capitalization of approximately $1.01 billion. The company is led by CEO Sushil Patel, who succeeded Philip Astley-Sparke (co-founder) as CEO in April 2024. Founder Robert Coffin serves as Chief Scientist. Replimune's financials reflect a clinical-stage company with no revenue, negative EBITDA, and significant R&D expenditures. The company faces challenges typical of biotech, including regulatory hurdles and clinical trial risks, but its innovative approach and strong pipeline offer potential for future cancer therapies.