Phio Pharmaceuticals Corp. (NASDAQ: PHIO) is a clinical-stage biopharmaceutical company headquartered in King of Prussia, Pennsylvania, with a focus on developing precision-targeted immuno-oncology therapies. The company was co-founded by Nobel Prize-winning scientist Craig Mello, who discovered RNA interference (RNAi), and was originally established as RXi Pharmaceuticals Corporation in 2003 before ...Phio Pharmaceuticals Corp. (NASDAQ: PHIO) is a clinical-stage biopharmaceutical company headquartered in King of Prussia, Pennsylvania, with a focus on developing precision-targeted immuno-oncology therapies. The company was co-founded by Nobel Prize-winning scientist Craig Mello, who discovered RNA interference (RNAi), and was originally established as RXi Pharmaceuticals Corporation in 2003 before rebranding to Phio Pharmaceuticals in November 2018. Phio leverages its proprietary INTASYL platform, a chemically modified small interfering RNA (siRNA) technology designed to silence specific genes that impede the immune system's anti-tumor response. The lead product candidate, PH-762, is being evaluated in multi-center Phase 1b dose-escalating clinical trials for the treatment of cutaneous squamous cell carcinoma (cSCC) by reducing PD-1 expression in tumor-infiltrating lymphocytes. Another candidate, PH-894, targets BRD4 to modulate gene expression in both T cells and tumor cells, currently in preclinical studies. The company's approach aims to enhance the body's immune cells to more effectively kill tumor cells, addressing significant unmet needs in oncology. As a clinical-stage entity, Phio has minimal revenue, with financial metrics indicating negative profitability and cash burn typical of biotech research. The company maintains a strong balance sheet with a current ratio of 15.87 and working capital of $13.4 million, supporting ongoing operations. Under the leadership of President and CEO Robert Bitterman, who has over 25 years of pharmaceutical development experience, Phio is advancing its pipeline through strategic research and development, with a small team of six full-time employees. The company's vision is to translate Nobel Prize-winning science into novel therapies that can transform cancer treatment, with a focus on precision medicine and immune modulation.